Error 1049 indicates that you may be trying to print a file sliced for a different 3D printer on your MakerBot Replicator.
if your .makerbot file sliced for the Fifth Generation MakerBot Replicator
A file sliced for a different kind of 3D printer won’t print on the MakerBot Replicator.
Open the original model in MakerBot Desktop and print or export it again. Make sure you have Replicator (5th Generation) selected as your device type in the Devices menu.
If you’re not able to print your file now
Okay. There may be something else going on with your software or firmware. Please open a case with MakerBot Support. Make sure to include your log files.
You can access the log files by going to MakerBot Desktop and selecting Help > Export Logs.